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April 24, 2014
Analysis of febrile malaria in Coastal Kenya paper

A new article, A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots by P Bejon et al has been published in eLife.

Malaria transmission is spatially heterogeneous. This reduces the efficacy of control strategies, but focusing control strategies on clusters or 'hotspots' of transmission may be highly effective. Among 1,500 homesteads in coastal Kenya we calculated a) the fraction of febrile children with positive malaria smears per homestead, and b) the mean age of children with malaria per homestead.

These two measures were inversely correlated, indicating that children in homesteads at higher transmission acquire immunity more rapidly. This inverse correlation increased gradually with increasing spatial scale of analysis, and hotspots of febrile malaria were identified at every scale. We found hotspots within hotspots, down to the level of an individual homestead. Febrile malaria hotspots were temporally unstable, but 4km radius hotspots could be targeted for one month following one month periods of surveillance.




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